(18)F-DG PET/CT in detection of recurrence and metastasis of colorectal cancer

World J Gastroenterol. 2007 Oct 7;13(37):5025-9. doi: 10.3748/wjg.v13.i37.5025.


Aim: To evaluate the value of (18)F-DG PET/CT in detecting recurrence and/or metastasis of colorectal cancer (CRC).

Methods: Combined visual analysis with semiquantitative analysis, the (18)F-DG PET/CT whole-body imaging results and the corresponding clinical data of 68 postoperative CRC patients including 48 male and 20 female with average age of 58.1 were analyzed retrospectively.

Results: Recurrence and/or metastasis were confirmed in 56 patients in the clinical follow-up after the PET/CT imaging. The sensitivity of PET/CT diagnosis of CRC recurrence and/or metastasis was 94.6%, and the specificity was 83.3%. The positive predictive value (PPV) was 96.4% and the negative predictive value (NPV) was 76.9%. PET/CT imaging detected one or more occult malignant lesions in 8 cases where abdominal/pelvic CT and/or ultrasonography showed negative findings, and also detected more lesions than CT or ultrasonography did in 30.4% (17/56) cases. Recurrence and/or metastasis was detected in 91.7% (22/24) cases with elevated serum CEA levels by (18)F-DG PET/CT imaging.

Conclusion: (18)F-DG PET/CT could detect the recurrence and/or metastasis of CRC with high sensitivity and specificity.

MeSH terms

  • Adult
  • Aged
  • Carcinoembryonic Antigen / blood
  • Colorectal Neoplasms / diagnostic imaging*
  • Colorectal Neoplasms / pathology
  • Female
  • Fluorodeoxyglucose F18
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Metastasis / diagnostic imaging*
  • Neoplasm Metastasis / pathology
  • Neoplasm Recurrence, Local / diagnostic imaging*
  • Neoplasm Recurrence, Local / pathology
  • Positron-Emission Tomography
  • Radiopharmaceuticals
  • Retrospective Studies
  • Tomography, X-Ray Computed


  • Carcinoembryonic Antigen
  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18