Room temperature-stable electride as a synthetic organic reagent: application to pinacol coupling reaction in aqueous media

Org Lett. 2007 Oct 11;9(21):4287-9. doi: 10.1021/ol701885p. Epub 2007 Sep 14.


Room temperature-stable inorganic electride [Ca(24)Al(28)O(68)](4+)4e(-) was employed for a pinacol coupling reaction in aqueous media. Ca-Al-O gel formed by the destruction of the crystal structure of an electride by water media played a key role in transferring the electron to electrophilic aldehydes. Aromatic aldehydes reacted smoothly with moderate to high yields.