Intrathoracic carcinoma in an 11-year-old girl showing a translocation t(15;19)

Am J Pediatr Hematol Oncol. 1991 Winter;13(4):459-64. doi: 10.1097/00043426-199124000-00011.


We report here a rare case of intrathoracic undifferentiated carcinoma in an 11-year-old girl. The biopsy tissue stained with antibodies against cytokeratin and carcino-embryonic antigen. The same staining was obtained using a cell line, PER-403, which was derived from the tumor. DNA from PER-403 cells was tested for the presence of Epstein-Barr virus genes, yielding a negative result. The cytogenetic analysis found a translocation t(15;19) (p12;q13), which has not previously been described in a carcinoma.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carcinoma / diagnostic imaging
  • Carcinoma / genetics*
  • Child
  • Chromosomes, Human, Pair 15*
  • DNA, Neoplasm / isolation & purification
  • Female
  • Humans
  • Immunohistochemistry
  • Karyotyping
  • Microscopy, Electron
  • Thoracic Neoplasms / diagnostic imaging
  • Thoracic Neoplasms / genetics*
  • Tomography, X-Ray Computed
  • Translocation, Genetic / genetics*
  • Tumor Cells, Cultured


  • DNA, Neoplasm