Placebo-controlled study of pramiracetam in young males with memory and cognitive problems resulting from head injury and anoxia

Brain Inj. Oct-Dec 1991;5(4):375-80. doi: 10.3109/02699059109008110.

Abstract

The current study evaluated under double-blind placebo-controlled conditions, the safety and efficacy of 400 mg pramiracetam sulphate TID in treating memory and other cognitive problems of males who have sustained brain injuries. The results of the study indicate that subject performance in measures of memory, especially delayed recall, evidenced clinically significant improvements after the administration of pramiracetam sulphate as compared to placebo. This improvement was maintained during an 18-month open-trial period on the medication as well as during a 1-month follow-up period after the pramiracetam was discontinued.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Amnesia / psychology
  • Amnesia / rehabilitation*
  • Brain Damage, Chronic / psychology
  • Brain Damage, Chronic / rehabilitation*
  • Brain Injuries / psychology
  • Brain Injuries / rehabilitation*
  • Double-Blind Method
  • Humans
  • Hypoxia, Brain / psychology
  • Hypoxia, Brain / rehabilitation*
  • Male
  • Mental Recall / drug effects
  • Middle Aged
  • Neurologic Examination
  • Neuropsychological Tests
  • Pyrrolidines / administration & dosage*
  • Pyrrolidines / adverse effects
  • Retention, Psychology / drug effects

Substances

  • Pyrrolidines
  • pramiracetam