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, 9 (21), 4155-8

Convenient Synthesis of Highly Functionalized Pyrazolines via Mild, Photoactivated 1,3-dipolar Cycloaddition

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Convenient Synthesis of Highly Functionalized Pyrazolines via Mild, Photoactivated 1,3-dipolar Cycloaddition

Yizhong Wang et al. Org Lett.

Abstract

A mild, photoactivated 1,3-dipolar cycloaddition procedure was successfully developed for the synthesis of polysubstituted pyrazolines. This procedure involved the in situ generation of the reactive nitrile imine dipoles using a hand-held UV lamp at 302 nm, followed by spontaneous cycloaddition with a broad range of 1,3-dipolarophiles with excellent solvent compatibility, functional group tolerance, regioselectivity, and yield.

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