Homogeneous 5-HT1D recognition sites in the human substantia nigra identified with a new iodinated radioligand

A T Bruinvels; B Landwehrmeyer; C Waeber; J M Palacios; D Hoyer

doi:10.1016/0014-2999(91)90257-q

Homogeneous 5-HT1D recognition sites in the human substantia nigra identified with a new iodinated radioligand

Eur J Pharmacol. 1991 Sep 4;202(1):89-91. doi: 10.1016/0014-2999(91)90257-q.

Authors

A T Bruinvels¹, B Landwehrmeyer, C Waeber, J M Palacios, D Hoyer

Affiliation

¹ Sandoz Pharma Ltd., Basel, Switzerland.

PMID: 1786802
DOI: 10.1016/0014-2999(91)90257-q

Abstract

The novel iodinated radioligand, serotonin-5-O-carboxymethyl-glycyl[125I] tyrosinamide, was used for binding studies with membranes of human substantia nigra. Evidence is provided for the existence in this tissue of a homogeneous population of recognition sites with the pharmacological profile of the 5-HT1D site.

MeSH terms

Dipeptides*
Humans
In Vitro Techniques
Iodine Radioisotopes
Receptors, Serotonin / drug effects
Receptors, Serotonin / metabolism*
Serotonin / analogs & derivatives*
Substantia Nigra / drug effects
Substantia Nigra / metabolism*

Substances

Dipeptides
Iodine Radioisotopes
Receptors, Serotonin
serotonin-O-carboxymethyl-Gly-Tyr
Serotonin