Onycholysis induced by nail hardener

Contact Dermatitis. 2007 Oct;57(4):280-1. doi: 10.1111/j.1600-0536.2007.01121.x.


Nail hardeners appeared in the market during the 1960s. They were basically solutions of formaldehyde. The first adverse effects were published in 1966 (1). Reactions were onycholysis, chromonychia, subungual haemorrhage, and hyperkeratosis. Onycholysis may be non-inflammatory or inflammatory, and is accompanied by throbbing pain. Inflammatory reactions are followed by paronychia and occasional dermatitis on the digital pulpa.

Publication types

  • Case Reports

MeSH terms

  • Cosmetics / adverse effects*
  • Cosmetics / chemistry
  • Dermatitis, Allergic Contact / etiology*
  • Female
  • Fixatives / adverse effects*
  • Formaldehyde / adverse effects*
  • Humans
  • Middle Aged
  • Nail Diseases / chemically induced*


  • Cosmetics
  • Fixatives
  • Formaldehyde