Effect of the LoBAG30 diet on blood glucose control in people with type 2 diabetes

Br J Nutr. 2008 Mar;99(3):511-9. doi: 10.1017/S0007114507819155. Epub 2007 Sep 10.

Abstract

In subjects with untreated type 2 diabetes, we previously determined that a weight-maintenance, non-ketogenic diet containing 30 % protein, 50 % fat and 20 % carbohydrate (30:50:20) decreased the percentage total glycohaemoglobin (%tGHb) by 2.2 % glycohaemoglobin over 5 weeks compared to a diet recommended for the American public (protein-fat-carbohydrate 15:30:55). Both the fasting and postprandial glucose were decreased. The objective of the present study was to determine if increasing the carbohydrate content from 20 to 30 % at the expense of fat would still provide a similar effect on %tGHb, fasting and postprandial glucose concentration. Eight men with untreated type 2 diabetes were studied over a 5-week period. Results at the beginning (standard diet) and end of the 5-week study were analysed. Body weight was stable. Fasting glucose concentration decreased by 40 %; 24 h glucose area response decreased by 45 %. Insulin did not change. Mean %tGHb decreased by 1.7 (from 10.8 to 9.1 %), and was still decreasing linearly at 5 weeks. In conclusion, a high-protein, 30 % carbohydrate diet could be a patient-empowering method of improving the hyperglycaemia of type 2 diabetes without pharmacologic intervention. Long-term effects and general applicability of this diet remain to be determined.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Aged
  • Blood Glucose / metabolism*
  • Body Weight
  • Cross-Over Studies
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / diet therapy*
  • Diabetes Mellitus, Type 2 / physiopathology
  • Diet, Diabetic*
  • Dietary Carbohydrates / administration & dosage*
  • Dietary Fats / administration & dosage
  • Dietary Proteins / administration & dosage*
  • Fasting / blood
  • Glycated Hemoglobin A / metabolism
  • Humans
  • Male
  • Middle Aged
  • Postprandial Period

Substances

  • Blood Glucose
  • Dietary Carbohydrates
  • Dietary Fats
  • Dietary Proteins
  • Glycated Hemoglobin A