Evaluation and differential diagnosis of marked, persistent eosinophilia

Immunol Allergy Clin North Am. 2007 Aug;27(3):529-49. doi: 10.1016/j.iac.2007.07.008.


Hypereosinophilic syndromes (HES) are a group of heterogeneous disorders many of which remain ill-defined. By definition, the HES must be distinguished from other disorders with persistently elevated eosinophilia with a defined cause. Although marked eosinophilia worldwide is most commonly caused by helminth (worm) infections, the diagnostic approach must include noninfectious (nonparasitic) causes of marked eosinophilia as well.

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Diagnosis, Differential
  • Eosinophilia* / diagnosis
  • Eosinophilia* / etiology
  • Eosinophilia* / physiopathology
  • Eosinophils / physiology*
  • Humans