Stabilization and encapsulation of photosensitive resveratrol within yeast cell

Int J Pharm. 2008 Feb 12;349(1-2):83-93. doi: 10.1016/j.ijpharm.2007.07.044. Epub 2007 Aug 10.

Abstract

The photosensitive resveratrol was successfully encapsulated in yeast cells for the first time, as characterized by FT-IR spectra, fluorescence and confocal micrographs of the yeast cells, resveratrol and microcapsules. The release characteristic of the obtained yeast-encapsulated resveratrol in simulated gastric fluid was evaluated, and its storage stability as a powder was investigated at 25 degrees C/75% relative humidity (RH), 25 degrees C/90% RH and 60 degrees C under the laboratory fluorescent lighting conditions (ca. 300 lx) or in the dark. Also, the scavenging capacity of yeast-encapsulated resveratrol on DPPH radical was compared with that of non-encapsulated resveratrol. It could be demonstrated clearly that no chemical changes occurred during the encapsulation. Besides, the DPPH radical-scavenging activity increased after the encapsulation. In addition, the yeast-encapsulated resveratrol exhibited good stability, and its bioavailability was enhanced as a result of increased solubility of resveratrol and sustained releasing.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biological Availability
  • Biphenyl Compounds
  • Chemistry, Pharmaceutical
  • Chromatography, High Pressure Liquid
  • Delayed-Action Preparations
  • Drug Compounding
  • Drug Stability
  • Drug Storage
  • Free Radical Scavengers / administration & dosage
  • Free Radical Scavengers / chemistry*
  • Hot Temperature
  • Light
  • Microscopy, Confocal
  • Microscopy, Fluorescence
  • Particle Size
  • Picrates / chemistry
  • Powders
  • Resveratrol
  • Saccharomyces cerevisiae / chemistry*
  • Solubility
  • Spectrophotometry, Ultraviolet
  • Spectroscopy, Fourier Transform Infrared
  • Stilbenes / administration & dosage
  • Stilbenes / chemistry*

Substances

  • Biphenyl Compounds
  • Delayed-Action Preparations
  • Free Radical Scavengers
  • Picrates
  • Powders
  • Stilbenes
  • 1,1-diphenyl-2-picrylhydrazyl
  • Resveratrol