Abstract
One phenol-quaternary ammonium salt derivative with a flexible linker and three derivatives with a quinazoline moiety are present. Their binding affinities for DNA are discussed and it is clearly demonstrated that this class of phenol-quaternary ammonium salt derivatives could inhibit DNA transcription effectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Binding Sites
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Cross-Linking Reagents / chemical synthesis*
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Cross-Linking Reagents / chemistry
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Cross-Linking Reagents / pharmacology
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DNA / drug effects
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DNA / genetics
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Hydrogen-Ion Concentration
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Molecular Structure
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Nucleic Acid Denaturation
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Phenols / chemistry*
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Quaternary Ammonium Compounds / chemistry*
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Quinazolines / chemical synthesis*
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Quinazolines / chemistry
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Quinazolines / pharmacology*
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Salts / chemistry
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Temperature
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Transcription, Genetic / drug effects
Substances
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Cross-Linking Reagents
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Phenols
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Quaternary Ammonium Compounds
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Quinazolines
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Salts
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DNA