Synthesis and biological activities of quinazoline derivatives with ortho-phenol-quaternary ammonium salt groups

Bioorg Med Chem. 2007 Nov 15;15(22):6920-6. doi: 10.1016/j.bmc.2007.07.053. Epub 2007 Aug 21.

Abstract

One phenol-quaternary ammonium salt derivative with a flexible linker and three derivatives with a quinazoline moiety are present. Their binding affinities for DNA are discussed and it is clearly demonstrated that this class of phenol-quaternary ammonium salt derivatives could inhibit DNA transcription effectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Binding Sites
  • Cross-Linking Reagents / chemical synthesis*
  • Cross-Linking Reagents / chemistry
  • Cross-Linking Reagents / pharmacology
  • DNA / drug effects
  • DNA / genetics
  • Hydrogen-Ion Concentration
  • Molecular Structure
  • Nucleic Acid Denaturation
  • Phenols / chemistry*
  • Quaternary Ammonium Compounds / chemistry*
  • Quinazolines / chemical synthesis*
  • Quinazolines / chemistry
  • Quinazolines / pharmacology*
  • Salts / chemistry
  • Temperature
  • Transcription, Genetic / drug effects

Substances

  • Cross-Linking Reagents
  • Phenols
  • Quaternary Ammonium Compounds
  • Quinazolines
  • Salts
  • DNA