Measuring disability and quality of life in established rheumatoid arthritis

Best Pract Res Clin Rheumatol. 2007 Oct;21(5):827-40. doi: 10.1016/j.berh.2007.05.004.


Rheumatoid arthritis is a chronic inflammatory disease with a major impact on physical and psychological health. It can cause severe disability and reduce health-related quality of life, aspects that are important to patients. Thus, it is important to measure disability and health-related quality of life in clinical practice and in clinical trials. This article presents an overview of the most important measures of outcome concerning disability and health-related quality of life, including different forms of the Health Assessment Questionnaire (HAQ, MHAQ, MDHAQ, HAQ II), visual analogue scales for fatigue and function, SF-36, Arthritis Impact Measurement Scales (AIMS/AIMS2), the Rheumatoid Arthritis Quality of Life (RAQoL) questionnaire, Nottingham Health Profile, Sickness Impact Profile and the utility instruments 15D, EQ-5D, SF-6D and Health Utilities Index (HUI) 2 and 3.

Publication types

  • Review

MeSH terms

  • Arthritis, Rheumatoid / physiopathology*
  • Arthritis, Rheumatoid / psychology
  • Disability Evaluation*
  • Disabled Persons / psychology
  • Humans
  • Outcome Assessment, Health Care*
  • Psychometrics
  • Quality of Life*
  • Sickness Impact Profile*
  • Surveys and Questionnaires