Timing of hepatitis B vaccination: its effect on vaccine response in health care workers

Vaccine. 2007 Oct 23;25(43):7568-72. doi: 10.1016/j.vaccine.2007.08.025. Epub 2007 Sep 4.


We assessed the effect of timing and other biological variables on immune response among health care workers (HCW) vaccinated with hepatitis B vaccine. A total of 2.058 HCW received three doses and were tested for anti-HBs within 6 months. 92.2% of the HCW had evidence of seroprotection. Multivariable analysis showed that controlling for age, the estimated non-response OR associated with a delayed second dose was 2.16 (95% CI: 1.46, 3.18, p=0.004). We found a decreasing response rate with increasing age. Particular attention should be given to those HCW who are late for the second vaccine dose and to older subjects.

MeSH terms

  • Adult
  • Age Factors
  • Female
  • Health Personnel*
  • Hepatitis B Antibodies / blood
  • Hepatitis B Vaccines / administration & dosage
  • Hepatitis B Vaccines / immunology*
  • Humans
  • Immunization Schedule
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Time Factors
  • Vaccination / methods*


  • Hepatitis B Antibodies
  • Hepatitis B Vaccines