Expanding the microcomedone theory and acne therapeutics: Propionibacterium acnes biofilm produces biological glue that holds corneocytes together to form plug

J Am Acad Dermatol. 2007 Oct;57(4):722-4. doi: 10.1016/j.jaad.2007.05.013.

Abstract

The Propionibacterium acnes biofilm has previously been shown to exist via genomic studies and to make a biological glue which allows for adherence to follicular walls. This gylcocalyx polymer secreted by P acnes also finds its way into sebum composition where it causes the adhesiveness of keratinocytes leading to comedones. An appreciation of P acnes biofilms and secretions has implications in immunogenicity of the organism, clinical course of acne, and therapy for comedonal and inflammatory acne.

Publication types

  • Editorial

MeSH terms

  • Acne Vulgaris / drug therapy
  • Acne Vulgaris / microbiology*
  • Acne Vulgaris / physiopathology*
  • Biofilms / drug effects
  • Dermatologic Agents / pharmacology
  • Dermatologic Agents / therapeutic use
  • Glycocalyx / physiology
  • Humans
  • Keratinocytes / physiology
  • Propionibacterium acnes / pathogenicity
  • Propionibacterium acnes / physiology*
  • Tissue Adhesives

Substances

  • Dermatologic Agents
  • Tissue Adhesives