A review of antibiotic resistance patterns of Streptococcus pneumoniae in Europe

J Antimicrob Chemother. 1991 Dec;28 Suppl C:31-8. doi: 10.1093/jac/28.suppl_c.31.


Streptococcus pneumoniae no longer has predictable antibiotic susceptibility. There are two areas of high prevalence of resistance (over 25%) to beta-lactam antibiotics in the South-West and North-East of Europe. In Spain, a close relationship has been found between the yearly rate of aminopenicillin consumption and penicillin resistance. High level resistance (MIC greater than or equal to 1 mg/L) has developed against a previous background of low level resistance. The serotypes involved in penicillin resistance in Spain are widespread in other countries. Macrolide resistance is high in France (over 15%) and is also increasing in other countries. All these resistant isolates remain susceptible to the most recent fluoroquinolones, such as temafloxacin. Prospective surveillance, more rational use of antibiotics and a diversification of antibiotic use in respiratory tract infections may serve to limit the threat of antibiotic resistance in S. pneumoniae.

Publication types

  • Review

MeSH terms

  • Drug Resistance, Microbial
  • Europe
  • Microbial Sensitivity Tests
  • Streptococcus pneumoniae / drug effects*