The effects of interleukin-1 beta on the activity of adrenal, splenic and renal sympathetic nerves in the rat

J Auton Nerv Syst. 1991 Dec;36(3):183-92. doi: 10.1016/0165-1838(91)90042-2.


The effects of intravenous (i.v.) administration of recombinant human interleukin-1 beta (rhIL-1 beta) on the activity of adrenal, splenic and renal sympathetic nerves were observed in urethane-anesthetized rats. An i.v. injection of IL-1 beta in doses of 10 pg-20 ng per animal (300-400 g, b.w.) resulted in a dose-dependent increase in the activity of the adrenal and splenic nerves, which lasted for more than 2-6 h. On the other hand, the activity of renal nerves showed a transient increase which was followed by a long-lasting suppression after injection of rhIL-1 beta (100 pg, i.v.). An i.v. injection of cyclooxygenase inhibitors (6 mg ibuprofen or 20 mg sodium salicylate) suppressed almost completely the rhIL-1 beta (100 pg)-induced activity in adrenal and splenic nerves. Although rhIL-1 beta (100 pg, i.v.) produced a fall in arterial blood pressure, baroreceptor denervation did not affect the excitatory responses of the adrenal and splenic nerves to rhIL-1 beta. The results suggest the regional differentiation of activity in the visceral sympathetic nerves in response to rhIL-1 beta. The rhIL-1 beta-induced activation of splenic sympathetic nerves implicates their involvement in the modulation of immunity by brain.

MeSH terms

  • Adrenal Glands / innervation*
  • Anesthesia
  • Animals
  • Blood Pressure / drug effects
  • Ibuprofen / pharmacology
  • Interleukin-1 / pharmacology*
  • Kidney / innervation*
  • Male
  • Neurons / drug effects*
  • Neurons, Efferent / drug effects
  • Rats
  • Rats, Inbred Strains
  • Recombinant Proteins / pharmacology
  • Sodium Salicylate / pharmacology
  • Spleen / innervation*
  • Sympathetic Nervous System / drug effects*


  • Interleukin-1
  • Recombinant Proteins
  • Sodium Salicylate
  • Ibuprofen