The Wnt signal transduction pathway in stem cells and cancer cells: influence on cellular invasion
- PMID: 17873378
- DOI: 10.1007/s12015-007-0001-y
The Wnt signal transduction pathway in stem cells and cancer cells: influence on cellular invasion
Abstract
The regulative network conducting adult stem cells in endogenous tissue repair is of prime interest for understanding organ regeneration as well as preventing degenerative and malignant diseases. One major signal transduction pathway which is involved in the control of these (patho)physiological processes is the Wnt pathway. Recent results obtained in our laboratories showed for the first time that canonical Wnt signaling is critically involved in the control of the migration/invasion behaviour of human mesenchymal stem cells (hMSC). In the first part of this review, we describe that the regenerative state is closely linked to the activation of the Wnt pathway. Central hallmarks of activated stem cells are recapitulated in a similar way also in cancer metastasis, where the acquisition of an invasive cancer stem cell phenotype is associated with the induction of Wnt-mediated epithelial to mesenchymal transition (EMT). In the second part, the influence of proinflammatory cytokines such as transforming growth factor (TGF-)beta1, interleukin (Il-)1beta, and tumor necrosis factor (TNF-)alpha is discussed with regard to the invasive characteristics of hMSC. In this context, special attention has been paid on the role of matrix metalloproteinases (MMPs), such as MMP-2, MMP-9 and membrane type 1 (MT1)-MMP, as well as on the tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2. Putative cross-talks between different signal transduction pathways that may amplify the invasive capacity of this stem cell population are also discussed. Finally, the consequences towards future drug-mediated therapeutical modifications of Wnt signaling in stem cells and tumor cells are highlighted.
Similar articles
-
Crosstalk between TGF-β signaling and miRNAs in breast cancer metastasis.Tumour Biol. 2016 Aug;37(8):10011-9. doi: 10.1007/s13277-016-5060-8. Epub 2016 May 6. Tumour Biol. 2016. PMID: 27153853 Review.
-
MT1-MMP Activation of TGF-β Signaling Enables Intercellular Activation of an Epithelial-mesenchymal Transition Program in Cancer.Curr Cancer Drug Targets. 2016;16(7):618-30. doi: 10.2174/1568009616666160216125634. Curr Cancer Drug Targets. 2016. PMID: 26881932
-
Wnt signaling regulates the invasion capacity of human mesenchymal stem cells.Stem Cells. 2006 Aug;24(8):1892-903. doi: 10.1634/stemcells.2005-0503. Epub 2006 May 11. Stem Cells. 2006. PMID: 16690780
-
Wnt signalling in mouse mesenchymal stem cells: impact on proliferation, invasion and MMP expression.J Cell Mol Med. 2009 Aug;13(8B):2506-2520. doi: 10.1111/j.1582-4934.2008.00619.x. Epub 2008 Dec 24. J Cell Mol Med. 2009. PMID: 19413884 Free PMC article.
-
Regulation of matrix metalloproteinases activity studied in human endometrium as a paradigm of cyclic tissue breakdown and regeneration.Biochim Biophys Acta. 2012 Jan;1824(1):146-56. doi: 10.1016/j.bbapap.2011.09.003. Epub 2011 Sep 24. Biochim Biophys Acta. 2012. PMID: 21982799 Review.
Cited by
-
Identification and validation of metastasis-related gene ZG16 in the prognosis and progression in colorectal cancer.Front Oncol. 2024 Jul 24;14:1409329. doi: 10.3389/fonc.2024.1409329. eCollection 2024. Front Oncol. 2024. PMID: 39114307 Free PMC article.
-
About a Possible Impact of Endodontic Infections by Fusobacterium nucleatum or Porphyromonas gingivalis on Oral Carcinogenesis: A Literature Overview.Int J Mol Sci. 2024 May 7;25(10):5083. doi: 10.3390/ijms25105083. Int J Mol Sci. 2024. PMID: 38791123 Free PMC article. Review.
-
NCAPD2 promotes the malignant progression of oral squamous cell carcinoma via the Wnt/β-catenin pathway.Cell Cycle. 2024 Mar;23(5):588-601. doi: 10.1080/15384101.2024.2348918. Epub 2024 May 14. Cell Cycle. 2024. PMID: 38743408 Free PMC article.
-
MicroRNA-191 regulates oral squamous cell carcinoma cells growth by targeting PLCD1 via the Wnt/β-catenin signaling pathway.BMC Cancer. 2023 Jul 17;23(1):668. doi: 10.1186/s12885-023-11113-9. BMC Cancer. 2023. PMID: 37460940 Free PMC article.
-
Aspirin inhibits proliferation and metastasis of canine mammary gland tumor cells through Wnt signaling axis.Transl Cancer Res. 2021 Feb;10(2):589-601. doi: 10.21037/tcr-20-3172. Transl Cancer Res. 2021. PMID: 35116393 Free PMC article.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical
Research Materials
Miscellaneous