How arginine-rich domains coordinate mRNA maturation events

RNA Biol. 2007 Aug;4(2):69-75. doi: 10.4161/rna.4.2.4869. Epub 2007 Aug 12.

Abstract

Maturation of RNA is highly regulated from transcription to post-transcriptional processing and localization to specific cellular compartments. The complexes that contribute to these events are in many cases well understood; however, many of the protein factors that coordinate and regulate these RNA processing events remain poorly characterized. Among them are arginine-rich domains, most commonly sequences rich in arginine/serine (RS domains) or arginine/glycine/glycine (RGG boxes), that often appear among factors and complexes involved in RNA processing. They are emerging as key yet poorly understood players in the assembly and coupling of RNA processing events.

Publication types

  • Review

MeSH terms

  • Animals
  • Arginine / analysis*
  • Arginine / metabolism
  • Binding Sites
  • Glycine / genetics
  • Glycine / metabolism
  • Humans
  • Methylation
  • Models, Biological
  • Protein Structure, Tertiary
  • RNA Precursors / metabolism*
  • RNA Processing, Post-Transcriptional*
  • RNA, Messenger / metabolism*
  • RNA-Binding Proteins / chemistry*
  • RNA-Binding Proteins / metabolism

Substances

  • RNA Precursors
  • RNA, Messenger
  • RNA-Binding Proteins
  • Arginine
  • Glycine