Estrogen receptor expression by peripheral blood mononuclear cells of patients with systemic lupus erythematosus

Clin Rheumatol. 2007 Oct;26(10):1675-8. doi: 10.1007/s10067-007-0568-3. Epub 2007 Feb 16.

Abstract

To investigate the influence of sex hormones on the development of systemic lupus erythematosus (SLE), we examined the estrogen receptor (ER) expression by peripheral blood mononuclear cells (PBMC) in patients with SLE using the real-time quantitative polymerase chain reaction (TaqMan) method. The expression of messenger RNA (mRNA) for ER alpha (ERa) was increased and expression of ER beta (ERb) mRNA was decreased in PBMC from SLE patients compared with PBMC from normal controls. These findings may be useful for elucidation of the pathophysiology of SLE.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Estrogen Receptor alpha / metabolism
  • Estrogen Receptor beta / metabolism
  • Estrogens / metabolism
  • Female
  • Gonadal Steroid Hormones / metabolism
  • Humans
  • Leukocytes, Mononuclear / metabolism*
  • Lupus Erythematosus, Systemic / blood*
  • Male
  • Middle Aged
  • RNA, Messenger / metabolism
  • Receptors, Estrogen / blood*
  • Sex Factors

Substances

  • Estrogen Receptor alpha
  • Estrogen Receptor beta
  • Estrogens
  • Gonadal Steroid Hormones
  • RNA, Messenger
  • Receptors, Estrogen