Interplay of microbe and major histocompatibility complex: a family study

J Rheumatol. 1991 Nov;18(11):1756-9.


We describe a 24-year-old man who developed reactive arthritis (ReA) after a dysenteric illness caused by Salmonella hadar. Serologic tests suggested recent exposure of family members to Salmonella. All members of the family were HLA-B27 positive, but no other family member developed acute ReA, although 2 of them had clinical evidence of previously existing B27 associated arthritis.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Arthritis, Infectious* / genetics
  • Cross Reactions
  • HLA-B Antigens / analysis
  • HLA-B27 Antigen / analysis
  • HLA-B27 Antigen / immunology
  • Humans
  • Immunoglobulins / analysis
  • Major Histocompatibility Complex*
  • Male
  • Pedigree
  • Phenotype
  • Prohibitins
  • Salmonella Infections* / immunology


  • HLA-B Antigens
  • HLA-B27 Antigen
  • HLA-B60 antigen
  • Immunoglobulins
  • PHB2 protein, human
  • Prohibitins