[Prophylactic effect of tropisetron hydrochloride against nausea and vomiting in patients receiving chemotherapy for hematological malignancies]

Gan To Kagaku Ryoho. 2007 Sep;34(9):1513-5.
[Article in Japanese]


To establish the effectiveness of oral 5-HT(3) antagonist, oral 5 mg tropisetron was introduced in the 21 cases with hematological malignancies for the prevention of chemotherapy-induced nausea and vomiting. Nausea and vomiting did not develop in 81% of patients receiving the tropisetron in this study. The results suggested that oral tropisetron is effective for the control of acute, and to a lesser extent, delayed, nausea and vomiting. The drug enhanced patients' quality of life and reduced the clinical cost. In conclusion, tropisetron is effective for the prevention of chemotherapy-induced nausea and vomiting in treatment for hematological malignancies. It is suitable as first-line therapy for outpatients.

MeSH terms

  • Administration, Oral
  • Adult
  • Aged
  • Antiemetics / administration & dosage*
  • Female
  • Hematologic Neoplasms / drug therapy*
  • Hematologic Neoplasms / physiopathology
  • Humans
  • Indoles / administration & dosage*
  • Male
  • Middle Aged
  • Nausea / chemically induced
  • Nausea / prevention & control*
  • Tropisetron
  • Vomiting / chemically induced
  • Vomiting / prevention & control*


  • Antiemetics
  • Indoles
  • Tropisetron