Temporal pole signal abnormality on MR imaging in temporal lobe epilepsy with hippocampal sclerosis: a fluid-attenuated inversion-recovery study

Arq Neuropsiquiatr. 2007 Sep;65(3A):553-60. doi: 10.1590/s0004-282x2007000400001.


Objective: To determine the frequency and regional involvement of temporal pole signal abnormality (TPA) in patients with hippocampal sclerosis (HS) using fluid-attenuated inversion-recovery (FLAIR) MR imaging, and to correlate this feature with history.

Method: Coronal FLAIR images of the temporal pole were assessed in 120 patients with HS and in 30 normal subjects, to evaluate gray-white matter demarcation.

Results: Ninety (75%) of 120 patients had associated TPA. The HS side made difference regarding the presence of TPA, with a left side prevalence (p=0.04, chi2 test). The anteromedial zone of temporal pole was affected in 27 (30%) out of 90 patients. In 63 (70%) patients the lateral zone were also affected. Patients with TPA were younger at seizure onset (p=0.018), but without association with duration of epilepsy.

Conclusion: Our FLAIR study show temporal pole signal abnormality in 3/4 of patients with HS, mainly seen on the anteromedial region, with a larger prevalence when the left hippocampus was involved.

Publication types

  • Controlled Clinical Trial

MeSH terms

  • Adolescent
  • Adult
  • Age of Onset
  • Brain Diseases / epidemiology
  • Brain Diseases / pathology*
  • Brazil / epidemiology
  • Chi-Square Distribution
  • Epilepsy, Temporal Lobe / epidemiology
  • Epilepsy, Temporal Lobe / pathology*
  • Female
  • Functional Laterality
  • Hippocampus / pathology*
  • Humans
  • Magnetic Resonance Imaging / methods
  • Male
  • Middle Aged
  • Sclerosis
  • Signal Processing, Computer-Assisted
  • Temporal Lobe / abnormalities*
  • Temporal Lobe / pathology*
  • Time Factors