SIRT1 transgenic mice show phenotypes resembling calorie restriction

Aging Cell. 2007 Dec;6(6):759-67. doi: 10.1111/j.1474-9726.2007.00335.x. Epub 2007 Sep 17.


We generated mice that overexpress the sirtuin, SIRT1. Transgenic mice have been generated by knocking in SIRT1 cDNA into the beta-actin locus. Mice that are hemizygous for this transgene express normal levels of beta-actin and higher levels of SIRT1 protein in several tissues. Transgenic mice display some phenotypes similar to mice on a calorie-restricted diet: they are leaner than littermate controls; are more metabolically active; display reductions in blood cholesterol, adipokines, insulin and fasted glucose; and are more glucose tolerant. Furthermore, transgenic mice perform better on a rotarod challenge and also show a delay in reproduction. Our findings suggest that increased expression of SIRT1 in mice elicits beneficial phenotypes that may be relevant to human health and longevity.

MeSH terms

  • Adipokines / blood
  • Animals
  • Blood Glucose / analysis
  • Caloric Restriction*
  • Cholesterol / blood
  • Insulin / blood
  • Longevity / genetics*
  • Mice
  • Mice, Transgenic
  • Phenotype
  • Sirtuin 1
  • Sirtuins / genetics
  • Sirtuins / metabolism*
  • Up-Regulation


  • Adipokines
  • Blood Glucose
  • Insulin
  • Cholesterol
  • Sirt1 protein, mouse
  • Sirtuin 1
  • Sirtuins