Risk of intracranial aneurysm bleeding in autosomal-dominant polycystic kidney disease

Kidney Int. 2007 Dec;72(11):1400-2. doi: 10.1038/sj.ki.5002488. Epub 2007 Sep 19.


Patients with autosomal-dominant polycystic kidney disease (ADPKD) carry an increased risk of developing intracranial aneurysms. Bleeding from these sites is a significant complication with the events reported to cluster in some families. In this study we determined if individualized risk of aneurysm rupture can be estimated based on family history using a Bayesian random effects model. Previously reported data were used to define distributions and to construct a model that fit these data. Our results confirm that intracerebral aneurysm bleeding in ADPKD patients tends to cluster in families and that basic family history can provide a simple estimate of family-specific risk.

MeSH terms

  • Aneurysm, Ruptured / etiology*
  • Aneurysm, Ruptured / genetics
  • Bayes Theorem
  • Humans
  • Intracranial Aneurysm / etiology*
  • Intracranial Aneurysm / genetics
  • Medical History Taking
  • Pedigree
  • Polycystic Kidney, Autosomal Dominant / complications*
  • Polycystic Kidney, Autosomal Dominant / genetics
  • Risk Factors