A Previously Unknown Dermal Blood Vessel Phenotype in Skin Inflammation

J Invest Dermatol. 2007 Dec;127(12):2893-900. doi: 10.1038/sj.jid.5701031. Epub 2007 Sep 20.


Podoplanin and lymphatic vascular endothelial hyaluronan receptor-1 (LYVE-1) are considered as lineage markers for lymphatic vessel (LV) endothelial cells (LECs). We have recently shown that IL-3 induces de novo expression of these genes in cultured blood vessel (BV) endothelial cells (BEC). To ask, if this is trans-differentiation or activation, we analyzed inflamed skin samples and cytokine-stimulated organ-cultured skin and found a subset of blood capillaries within the papillary dermis expressing low amounts of podoplanin and LYVE-1 as well as high amounts of cytokine-inducible adhesion molecules. In contrast, neighboring lymphatic capillaries express high amounts of podoplanin, LYVE-1 and low amounts of cytokine-inducible adhesion molecules. The different response patterns to inflammatory stimuli were reproducible in cell culture, when cytokine-stimulated BEC and LEC were analyzed. These findings signify that expression of "lymphatic proteins" on BEC corresponds to cell activation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blood Vessels / metabolism
  • Blood Vessels / pathology*
  • Capillaries / metabolism
  • Cell Lineage
  • Cells, Cultured
  • E-Selectin / biosynthesis
  • Endothelial Cells / metabolism
  • Humans
  • Inflammation / pathology*
  • Intercellular Adhesion Molecule-1 / biosynthesis
  • Interleukin-3 / metabolism
  • Lymphatic Vessels / metabolism
  • Phenotype
  • Skin / blood supply
  • Skin / pathology*
  • Vascular Cell Adhesion Molecule-1 / biosynthesis
  • Vesicular Transport Proteins / biosynthesis


  • E-Selectin
  • Interleukin-3
  • LYVE1 protein, human
  • Vascular Cell Adhesion Molecule-1
  • Vesicular Transport Proteins
  • Intercellular Adhesion Molecule-1