Modelling and control of HIV dynamics

Comput Methods Programs Biomed. 2008 Feb;89(2):162-8. doi: 10.1016/j.cmpb.2007.08.003. Epub 2007 Sep 19.


Various models of HIV infection and evolution have been considered in the literature. This paper considers a variant of the Wodarz and Nowak mathematical model, adding "aggressiveness" as a new state variable in order to quantify the strength of the virus and its response to drugs. Although the model proposed is relatively simple, simulation results suggest that it may be useful in predicting the impact of the effectiveness of therapy on HIV dynamics.

MeSH terms

  • Antiretroviral Therapy, Highly Active
  • HIV Infections / drug therapy*
  • HIV Infections / physiopathology
  • Humans
  • Italy
  • Models, Biological*
  • Models, Statistical*
  • Viral Load / statistics & numerical data