Evaluation of a live, attenuated respiratory syncytial virus vaccine in infants

J Pediatr. 1976 Jun;88(6):931-6. doi: 10.1016/s0022-3476(76)81044-x.


Respiratory syncytial virus ts-1 is a live attenuated experimental vaccine which was administered intranasally to 25 infants 11 to 19 months of age. Clinical evaluation was carried out following a controlled, double-blind protocol which eliminated observer bias, assessed intercurrent illness, and was designed to detect virus transmission. At the low dose of virus of virus used (100 TCID50) 8 of the 25 recipients were successfully infected with RS virus ts-1 as determined by virus shedding or antibody response.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Antibodies, Viral / analysis
  • Humans
  • Infant
  • Orthomyxoviridae Infections / prevention & control
  • Respiratory Syncytial Viruses / immunology*
  • Respiratory Tract Infections / prevention & control
  • Vaccination
  • Vaccines, Attenuated* / administration & dosage
  • Viral Vaccines* / administration & dosage


  • Antibodies, Viral
  • Vaccines, Attenuated
  • Viral Vaccines