Ethical issues in adolescent and parent informed consent for pediatric asthma research participation

J Asthma. 2007 Sep;44(7):489-96. doi: 10.1080/02770900701247137.


This article reviews the empirical literature related to knowledge, competence, volition, and financial compensation in the biomedical research decision-making of children, adolescents, and parents. Research findings indicate there are differences in adolescent and parent understanding and appreciation of research risks and procedures, that opinions about decision-making authority and physician influence for research participation are different in adolescents and parents, and that financial compensation can be a salient factor in the research-related decision-making process. Pediatric asthma researchers can consider these psychological factors involved in adolescent and parent research participation decision-making processes to develop effective informed consent procedures.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Adolescent
  • Asthma / therapy*
  • Biomedical Research / ethics*
  • Child
  • Decision Making*
  • Ethics, Research*
  • Humans
  • Informed Consent / ethics*
  • Mental Competency / psychology
  • Parental Consent / ethics
  • Patient Participation / psychology
  • Perception
  • Psychology, Adolescent
  • Risk Assessment
  • Volition