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. 2008 Feb;22(2):141-8.
doi: 10.1002/ptr.2295.

Antiviral Effects of Glycyrrhiza Species

Free PMC article

Antiviral Effects of Glycyrrhiza Species

Cristina Fiore et al. Phytother Res. .
Free PMC article


Historical sources for the use of Glycyrrhiza species include ancient manuscripts from China, India and Greece. They all mention its use for symptoms of viral respiratory tract infections and hepatitis. Randomized controlled trials confirmed that the Glycyrrhiza glabra derived compound glycyrrhizin and its derivatives reduced hepatocellular damage in chronic hepatitis B and C. In hepatitis C virus-induced cirrhosis the risk of hepatocellular carcinoma was reduced. Animal studies demonstrated a reduction of mortality and viral activity in herpes simplex virus encephalitis and influenza A virus pneumonia. In vitro studies revealed antiviral activity against HIV-1, SARS related coronavirus, respiratory syncytial virus, arboviruses, vaccinia virus and vesicular stomatitis virus. Mechanisms for antiviral activity of Glycyrrhiza spp. include reduced transport to the membrane and sialylation of hepatitis B virus surface antigen, reduction of membrane fluidity leading to inhibition of fusion of the viral membrane of HIV-1 with the cell, induction of interferon gamma in T-cells, inhibition of phosphorylating enzymes in vesicular stomatitis virus infection and reduction of viral latency. Future research needs to explore the potency of compounds derived from licorice in prevention and treatment of influenza A virus pneumonia and as an adjuvant treatment in patients infected with HIV resistant to antiretroviral drugs.

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    1. Abe N, Ebina T, Ishida N. 1982. Interferon induction by glycyrrhizin and glycyrrhetinic acid in mice. Microbiol Biol 26: 535–539. - PubMed
    1. Acharya SK, Dasarathy S, Tandon A, Joshi YK, Tandon BN. 1993. A preliminary open trial on interferon stimulator (SNMC) derived from Glycyrrhiza glabra in the treatment of subacute hepatic failure. Indian J Med Res 98: 69–74. - PubMed
    1. Arase Y, Ikeda K, Murashima N et al. 1997. The long term efficacy of glycyrrhizin in chronic hepatitis C patients. Cancer 79: 1494–1500. - PubMed
    1. Armanini D, Fiore C, Bielenberg J, Ragazzi E. 2005. Licorice (Glycyrrhiza glabra) In Encyclopedia of Dietary Supplements, Coates P, editor. (ed.). Marcel Dekker Inc.: New York, 391–399.
    1. Armanini D, Fiore C, Matterello MJ, Bielenberg J, Palermo M. 2002. History of the endocrine effects of licorice. Exp Clin Endocrinol Diabet 110: 257–261. - PubMed