The integrin-growth factor receptor duet

J Cell Physiol. 2007 Dec;213(3):649-53. doi: 10.1002/jcp.21278.


Cell adhesion receptors, referred to as integrins, are recognized as key regulators of cellular processes including growth and differentiation. Integrins communicate with growth factor receptors (GFRs) to control specific cellular responses to stimuli originating in the extracellular environment. In this article, we review the role of integrins as molecular switches that modulate GFR activation and specificity. We also examine the reciprocal modulation of integrin functions by GFRs and the mechanisms through which those actions are fine-tuned.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Forecasting
  • Humans
  • Integrins / metabolism*
  • Ligands
  • Models, Biological
  • Receptors, Growth Factor / metabolism*


  • Integrins
  • Ligands
  • Receptors, Growth Factor