Abstract
Three hydrazone ligands, H2L1-H2L3, made from salicylaldehyde and ibuprofen- or naproxen-derived hydrazides, were prepared and transformed into the corresponding copper(II) complexes [Cu(II)L1] x H2O, [Cu(II)L2], and [(Cu(II))2(L3)2] x H2O x DMF (Scheme). The X-ray crystal structure of the last-mentioned complex was solved (Fig. 1), showing a square-planar complexation geometry, and the single units were found to form a one-dimensional chain structure (Fig. 2). The interactions of these complexes with CT-DNA were studied by different techniques, indicating that they all bind to DNA by classical and/or non-classical intercalation modes.
MeSH terms
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Aldehydes / chemistry*
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Copper / chemistry
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Crystallography, X-Ray
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DNA / chemistry
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Hydrazones / chemical synthesis
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Hydrazones / chemistry*
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Intercalating Agents / chemical synthesis
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Intercalating Agents / chemistry*
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Molecular Structure
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Organometallic Compounds / chemical synthesis
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Organometallic Compounds / chemistry*
Substances
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(N'-((2-hydroxyphenyl)methylidene)-2-(6-methoxynaphthalen-2-yl)propanehydrazide)copper(II)
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(N1-((2-hydroxyphenyl)methylidene)-2-(4-(2-methylpropyl)phenyl)propanehydrazide)copper(II)
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Aldehydes
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Hydrazones
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Intercalating Agents
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Organometallic Compounds
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bis(N'-((2-hydroxyphenyl)methylidene)-2-(6-methoxynaphthalen-2-yl)propanehydrazide)dicopper(II)
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salicylaldehyde
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Copper
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DNA