A more serine way to die: defining the characteristics of serine protease-mediated cell death cascades

Biochim Biophys Acta. 2007 Oct;1773(10):1491-9. doi: 10.1016/j.bbamcr.2007.08.002. Epub 2007 Aug 14.


The morphological features observed by Kerr, Wylie and Currie in 1972 define apoptosis, necrosis and autophagy. An appreciable number of alternative systems do not fall neatly under these categories, warranting a review of alternative proteolytic machinery and its contribution to cell death. This review aims to pinpoint key molecular features of serine protease-mediated pro-apoptotic signalling. The profile created will contribute to a standard set of biochemical criteria that can serve in differentiating within cell death subtypes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis / physiology
  • Cell Death / physiology*
  • Granzymes / metabolism
  • High-Temperature Requirement A Serine Peptidase 2
  • Humans
  • Mitochondria / metabolism
  • Mitochondrial Proteins / metabolism
  • Serine Endopeptidases / metabolism
  • Serine Endopeptidases / physiology*
  • Signal Transduction
  • Urokinase-Type Plasminogen Activator / metabolism


  • Mitochondrial Proteins
  • AP24 apoptotic protease
  • Granzymes
  • Serine Endopeptidases
  • High-Temperature Requirement A Serine Peptidase 2
  • Urokinase-Type Plasminogen Activator