Influence of TRPV3 mutation on hair growth cycle in mice

Biochem Biophys Res Commun. 2007 Nov 23;363(3):479-83. doi: 10.1016/j.bbrc.2007.08.170. Epub 2007 Sep 6.


We recently reported that Gly573Ser substitution of the transient receptor potential cation channel, subfamily V member 3 (TRPV3) caused hair loss in DS-Nh mice. To further elucidate the effects of this mutation on the development of the spontaneous hairless phenotype, we examined the temperature-response to epidermal sheets from DS-Nh and DS mice. It was indicated that the mutation was gain-of-function. We also performed genetic and histological analyses with both strain skins. DNA microarray data revealed that the levels of keratin-associated protein 16-1, 16-3, and 16-9 genes related to the anagen phase were decreased in the skins of DS-Nh mice compared with those of three days old DS mice. Histological analysis revealed that the anagen phase persisted in DS-Nh mice, and that the telogen phase was seen in DS but not DS-Nh mice at 21 days of age. Regulation of TRPV3 appears to be important for appropriate hair development in rodents.

MeSH terms

  • Animals
  • Biological Transport
  • Calcium / metabolism
  • Calcium / pharmacokinetics
  • Epidermal Cells
  • Epidermis / metabolism
  • Female
  • Gene Expression Profiling
  • Hair / growth & development*
  • Hair / metabolism
  • Hair Follicle / growth & development
  • Hair Follicle / metabolism
  • Male
  • Mice
  • Mice, Hairless
  • Mutation*
  • Oligonucleotide Array Sequence Analysis
  • Phenotype
  • Reverse Transcriptase Polymerase Chain Reaction
  • TRPV Cation Channels / genetics
  • TRPV Cation Channels / physiology*
  • Time Factors


  • TRPV Cation Channels
  • Trpv3 protein, mouse
  • Calcium