E-selectin and TFPI Are Associated With Carotid Intima-Media Thickness in Stable IHD Patients: The Baseline Findings of the MIAMI Study

Nutr Metab Cardiovasc Dis. 2008 May;18(4):320-8. doi: 10.1016/j.numecd.2007.01.008. Epub 2007 Sep 21.

Abstract

Objective: MIAMI was a prospective multicenter clinical study designed to investigate the relationship between changes in carotid intima-media thickness (C-IMT) and those in the levels of circulating markers of inflammation, thrombosis and endothelial dysfunction. The study was performed in a group of stable coronary patients treated for two years with a moderate dosage of atorvastatin (20mg/day). In this paper the cross-sectional relationship between C-IMT and the same circulating markers of inflammation, thrombosis and endothelial dysfunction measured at baseline was investigated.

Methods: Eighty-five subjects that had not used statins for at least two months were enrolled in the study. At time of enrollment, the levels of vascular cell adhesion molecule-1 (VCAM-1), intracellular adhesion molecule-1 (ICAM-1), E-selectin, interleukin (IL)-6, IL-8, tumor necrosis factor (TNF)-alpha, high-sensitivity C-reactive protein (hs-CRP), tissue factor (TF), tissue factor pathway inhibitor (TFPI), von Willebrand factor (vWF), fibrinogen, total cholesterol (TC), high-density lipoprotein (HDL) and low-density lipoprotein (LDL), and triglycerides were measured, in parallel with C-IMT assessment.

Results: In cross-sectional analyses, markers of endothelial perturbation (i.e. E-selectin) and TFPI were more strongly correlated with arherosclerotic burden than markers of inflammation. The baseline picture in this study indicates that E-selectin and TFPI are linked with atherosclerotic burden.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Atorvastatin
  • Biomarkers / blood
  • C-Reactive Protein / metabolism
  • Carotid Artery Diseases / blood*
  • Carotid Artery Diseases / etiology
  • Cholesterol / blood
  • E-Selectin / blood*
  • Endothelium, Vascular / physiopathology*
  • Female
  • Fibrinogen / metabolism
  • Heptanoic Acids / therapeutic use
  • Humans
  • Inflammation / blood
  • Inflammation / physiopathology*
  • Intercellular Adhesion Molecule-1 / blood
  • Interleukin-6 / blood
  • Interleukin-8 / blood
  • Lipoproteins / blood*
  • Male
  • Middle Aged
  • Prospective Studies
  • Pyrroles / therapeutic use
  • Thromboplastin / metabolism
  • Triglycerides / blood
  • Tumor Necrosis Factor-alpha / blood
  • Tunica Intima / pathology*
  • Vascular Cell Adhesion Molecule-1 / blood
  • von Willebrand Factor / metabolism

Substances

  • Biomarkers
  • E-Selectin
  • Heptanoic Acids
  • Interleukin-6
  • Interleukin-8
  • Lipoproteins
  • Pyrroles
  • Triglycerides
  • Tumor Necrosis Factor-alpha
  • Vascular Cell Adhesion Molecule-1
  • lipoprotein-associated coagulation inhibitor
  • von Willebrand Factor
  • Intercellular Adhesion Molecule-1
  • Fibrinogen
  • C-Reactive Protein
  • Thromboplastin
  • Cholesterol
  • Atorvastatin