Non-oncogene Addiction and the Stress Phenotype of Cancer Cells

Cell. 2007 Sep 21;130(6):986-8. doi: 10.1016/j.cell.2007.09.007.

Abstract

Heat-shock factor 1 (HSF1) is a transcription factor that is activated upon proteotoxic stress and coordinates induction of the heat-shock response. In this issue, Dai et al. (2007) show that HSF1 is a potent modifier of tumorigenesis and is required for tumor initiation and maintenance in a variety of cancer models. These findings add HSF1 to a growing list of non-oncogenes that could be exploited as cancer drug targets.

Publication types

  • Comment

MeSH terms

  • Animals
  • Carcinogens
  • Cell Line, Tumor
  • Cell Proliferation
  • Cell Survival
  • Cell Transformation, Neoplastic / genetics
  • Cell Transformation, Neoplastic / metabolism*
  • Cell Transformation, Neoplastic / pathology
  • DNA-Binding Proteins / deficiency
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism*
  • Gene Expression Regulation, Neoplastic*
  • Genotype
  • Glucose / metabolism
  • Heat Shock Transcription Factors
  • Humans
  • Mice
  • Mice, Knockout
  • Mutation
  • Phenotype
  • Protein Biosynthesis
  • Proto-Oncogene Proteins c-sis / genetics
  • Proto-Oncogene Proteins c-sis / metabolism
  • Signal Transduction / genetics
  • Skin / metabolism*
  • Skin / pathology
  • Skin Neoplasms / chemically induced
  • Skin Neoplasms / genetics
  • Skin Neoplasms / metabolism*
  • Skin Neoplasms / pathology
  • Stress, Physiological / genetics
  • Stress, Physiological / metabolism*
  • Stress, Physiological / pathology
  • Time Factors
  • Transcription Factors / deficiency
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*
  • Tumor Suppressor Protein p53 / genetics
  • Tumor Suppressor Protein p53 / metabolism
  • ras Proteins / genetics
  • ras Proteins / metabolism

Substances

  • Carcinogens
  • DNA-Binding Proteins
  • HSF1 protein, human
  • Heat Shock Transcription Factors
  • Hsf1 protein, mouse
  • Proto-Oncogene Proteins c-sis
  • Transcription Factors
  • Tumor Suppressor Protein p53
  • ras Proteins
  • Glucose