YAP1 meets tumor suppression

Mol Cell. 2007 Sep 21;27(6):863-4. doi: 10.1016/j.molcel.2007.09.004.

Abstract

In this issue of Molecular Cell, Matallanas et al. (2007) demonstrate that RASSF1A-induced apoptosis impinges on the transcriptional coactivator YAP1, whose nuclear translocation and binding to p73 result in proper execution of the cell death pathway. Indeed, RASSF1A silencing in tumors inhibits YAP1-p73-dependent apoptosis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Adaptor Proteins, Signal Transducing / metabolism*
  • Apoptosis
  • DNA-Binding Proteins / metabolism*
  • Humans
  • Nuclear Proteins / metabolism*
  • Phosphoproteins / metabolism*
  • Protein Binding
  • Protein-Serine-Threonine Kinases / metabolism
  • Proto-Oncogene Proteins c-raf / metabolism
  • Transcription Factors
  • Transcription, Genetic
  • Tumor Protein p73
  • Tumor Suppressor Protein p53 / metabolism
  • Tumor Suppressor Proteins / metabolism*

Substances

  • Adaptor Proteins, Signal Transducing
  • DNA-Binding Proteins
  • Nuclear Proteins
  • Phosphoproteins
  • RASSF1 protein, human
  • TP73 protein, human
  • Transcription Factors
  • Tumor Protein p73
  • Tumor Suppressor Protein p53
  • Tumor Suppressor Proteins
  • YAP1 protein, human
  • LATS1 protein, human
  • STK3 protein, human
  • Protein-Serine-Threonine Kinases
  • Proto-Oncogene Proteins c-raf