Intraocular pressure rise after primary posterior continuous curvilinear capsulorhexis with a fixed dorzolamide-timolol combination: randomized safety study with intraindividual comparison using an angulated and a nonangulated intraocular lens

J Cataract Refract Surg. 2007 Oct;33(10):1754-9. doi: 10.1016/j.jcrs.2007.05.039.


Purpose: To assess the safety, in terms of the intraocular pressure (IOP), of cataract surgery with primary posterior continuous curvilinear capsulorhexis (PPCCC) and a postoperative dose of a fixed dorzolamide-timolol combination and evaluate the effect of intraocular lens (IOL) haptic angulation.

Setting: Department of Ophthalmology, Medical University of Vienna, Vienna, Austria.

Methods: In this prospective randomized double-masked bilateral study, 88 eyes of 44 consecutive patients with age-related cataract were included in an intraindividual comparison study. All patients had standardized cataract surgery with PPCCC and IOL implantation in the capsular bag followed by a postoperative dose of a fixed dorzolamide-timolol combination. Patients were randomly assigned to receive an ACR6D SE IOL (Laboratoires Cornéal) in 1 eye and a Centerflex (C-flex) 570C IOL (Rayner Surgical GmbH) in the contralateral eye. The IOP was measured at baseline and postoperatively at 6 and 24 hours as well as 1 week.

Results: Intraindividual comparison showed statistically significantly higher IOP measurements in the C-flex 570C nonangulated IOL group than in the ACR6D SE angulated IOL group at 24 hours (P = .003) and 1 week (P = .043). The highest IOP spikes (34 mm Hg) were at 6 hours in 2 eyes with a C-flex 570C IOL. The ACR6D SE group had statistically significant changes in IOP between preoperative and all postoperative time points. In the C-flex 570C group, the only statistically significant change in IOP was between preoperatively and 6 hours postoperatively.

Conclusions: Cataract surgery with PPCCC was safe in terms of the postoperative IOP course. Haptic angulation slightly decreased the overall IOP rise and the incidence of IOP rises above 30 mm Hg.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Aged, 80 and over
  • Antihypertensive Agents / administration & dosage*
  • Antihypertensive Agents / adverse effects
  • Capsulorhexis / methods*
  • Cataract / complications
  • Combined Modality Therapy
  • Double-Blind Method
  • Drug Therapy, Combination
  • Female
  • Humans
  • Intraocular Pressure*
  • Lens Implantation, Intraocular
  • Lenses, Intraocular*
  • Male
  • Middle Aged
  • Ocular Hypertension / prevention & control*
  • Postoperative Complications
  • Prospective Studies
  • Prosthesis Design
  • Sulfonamides / administration & dosage*
  • Sulfonamides / adverse effects
  • Thiophenes / administration & dosage*
  • Thiophenes / adverse effects
  • Timolol / administration & dosage*
  • Timolol / adverse effects


  • Antihypertensive Agents
  • Sulfonamides
  • Thiophenes
  • Timolol
  • dorzolamide