Skinfold thickness, local subcutaneous blood flow and insulin absorption in diabetic patients

Acta Physiol Scand Suppl. 1991;603:41-5.

Abstract

The influence of skinfold thickness on the local subcutaneous blood flow (SBF) and absorption rate of subcutaneously injected and infused soluble insulin was investigated in insulin-dependent diabetic patients. The local 133Xenon washout technique was used for measuring SBF and the disappearance of 125I labelled insulin for measuring insulin absorption. A Harpenden skinfold caliper was used for measuring skinfold thickness. A large variation in skinfold thickness (range 6-40 mm, N = 50) was demonstrated. The SBF was curvilinear related to the skinfold thickness with decreasing SBF for increasing skinfold thickness (N = 50). A similar relationship was found between the SBF and the absorption rate of subcutaneously injected (N = 10) and infused (N = 7) insulin. The large variation in skinfold thickness and thus insulin absorption may partly explain the well-known large inter-individual variation in insulin absorption, and the different absorption rates from areas with different skinfold thickness should be taken into account when treating with insulin.

MeSH terms

  • Absorption
  • Adolescent
  • Adult
  • Blood Flow Velocity
  • Connective Tissue / blood supply
  • Diabetes Mellitus, Type 1 / drug therapy
  • Diabetes Mellitus, Type 1 / pathology
  • Diabetes Mellitus, Type 1 / physiopathology*
  • Female
  • Humans
  • Injections, Subcutaneous
  • Insulin / administration & dosage
  • Insulin / pharmacokinetics*
  • Male
  • Middle Aged
  • Skinfold Thickness

Substances

  • Insulin