The characteristics of relapse in adult-onset minimal-change nephrotic syndrome

Clin Exp Nephrol. 2007 Sep;11(3):214-217. doi: 10.1007/s10157-007-0484-5. Epub 2007 Sep 28.


Background: Although minimal-change nephrotic syndrome (MCNS) is highly steroid-responsive, the frequency of relapses in some patients is high, necessitating the administration of repeated courses of prednisolone in high doses. It is, therefore, necessary to identify factors that can predict this increased risk of relapse in some patients in order to establish useful treatment methods to reduce the risk.

Methods: To clarify the factors that might increase the risk of relapses, the data of 82 Japanese adult patients with MCNS receiving treatment at our department were analyzed retrospectively. Of the total, 55 patients (67.1%) experienced relapse after showing an initial response. We divided the patients into two groups; namely, the nonrelapse group (n = 27) and the relapse group (n = 55), and compared the clinico-pathophysiological characteristics between the two groups.

Results: Significantly increased serum immunoglobulin E (IgE) levels (P = 0.0002) and increased frequency of steroid side effects were observed in the relapse group as compared to the nonrelapse group.

Conclusions: To develop effective therapeutic modalities, it is important to have a thorough understanding of the clinico-pathophysiological characteristics of MCNS patients showing relapse.

MeSH terms

  • Adult
  • Female
  • Glucocorticoids / adverse effects
  • Glucocorticoids / therapeutic use*
  • Humans
  • Immunoglobulin E / blood*
  • Male
  • Middle Aged
  • Nephrosis, Lipoid / blood
  • Nephrosis, Lipoid / drug therapy
  • Nephrosis, Lipoid / physiopathology*
  • Prednisolone / adverse effects
  • Prednisolone / therapeutic use*
  • Recurrence
  • Retrospective Studies


  • Glucocorticoids
  • Immunoglobulin E
  • Prednisolone