Pericytes: Gatekeepers in Tumour Cell Metastasis?

J Mol Med (Berl). 2008 Feb;86(2):135-44. doi: 10.1007/s00109-007-0258-2. Epub 2007 Sep 22.

Abstract

Tumour cells use two major routes to spread during metastasis, e.g. lymph vessels and blood vessels within or surrounding the primary tumour. The growth rate of the primary tumour often correlates with the quantity of new blood vessels that form within the tumour. However, qualitative abnormalities of the tumour vasculature profoundly affect the perfusion of the primary tumour and the escape of tumour cells into the circulation. In this paper, we review recent evidence for a novel role of the supporting mural cells in limiting blood-borne metastasis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Angiogenesis Inhibitors / pharmacology
  • Angiogenesis Inhibitors / therapeutic use
  • Animals
  • Becaplermin
  • Cell Adhesion
  • Cell Movement
  • Endothelial Cells / metabolism
  • Extracellular Matrix / metabolism
  • Humans
  • Neoplasm Invasiveness
  • Neoplasm Metastasis
  • Neoplasms / blood supply
  • Neoplasms / drug therapy
  • Neoplasms / metabolism*
  • Neoplasms / pathology
  • Neoplastic Cells, Circulating / drug effects
  • Neoplastic Cells, Circulating / metabolism*
  • Neoplastic Cells, Circulating / pathology
  • Neovascularization, Pathologic / metabolism*
  • Neovascularization, Pathologic / prevention & control
  • Neural Cell Adhesion Molecules / metabolism
  • Pericytes / drug effects
  • Pericytes / metabolism*
  • Pericytes / pathology
  • Platelet-Derived Growth Factor / metabolism
  • Proto-Oncogene Proteins c-sis
  • Signal Transduction* / drug effects
  • Stromal Cells / metabolism

Substances

  • Angiogenesis Inhibitors
  • Neural Cell Adhesion Molecules
  • Platelet-Derived Growth Factor
  • Proto-Oncogene Proteins c-sis
  • Becaplermin