The CASP8 -652 6N del promoter polymorphism and breast cancer risk: a multicenter study

Breast Cancer Res Treat. 2008 Sep;111(1):139-44. doi: 10.1007/s10549-007-9752-z. Epub 2007 Sep 21.

Abstract

A recent study on an Asian population reported a six-nucleotide insertion-deletion polymorphism (-652 6N del) in the CASP8 promoter region to be strongly associated with a decreased risk of multiple types of cancer, including breast cancer (BC). Here, we investigate the effect of this deletion in four independent large European BC case-control studies, including data from a total of 7,753 cases and 7,921 controls. The combined per allele odds ratio (OR) was 0.97 (95% confidence interval (CI), 95% CI = 0.93-1.02). The present result indicates that the CASP8 -652 6N del variant has no significant effect on BC risk in Europeans.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Base Sequence*
  • Breast Neoplasms / genetics*
  • Case-Control Studies
  • Caspase 8 / genetics*
  • European Continental Ancestry Group
  • Female
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Middle Aged
  • Polymorphism, Genetic*
  • Promoter Regions, Genetic / genetics*
  • Risk Factors
  • Sequence Deletion*
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Substances

  • Caspase 8