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Comparative Study
. 1977 May;17(1):157-64.

Bioenergetics in Clinical Medicine XV. Inhibition of Coenzyme Q10-enzymes by Clinically Used Adrenergic Blockers of Beta-Receptors

  • PMID: 17892
Comparative Study

Bioenergetics in Clinical Medicine XV. Inhibition of Coenzyme Q10-enzymes by Clinically Used Adrenergic Blockers of Beta-Receptors

T Kishi et al. Res Commun Chem Pathol Pharmacol. .

Abstract

Adrenergic blockers for beta-receptors were studied for inhibition of mitochrondrial CoQ10-enzymes. These enzymes are indispensable for the bioenegetics of the myocardium. Propranolol is frequently used to treat hypertension; in some patients, it depresses myocardial function as an adverse reaction. This side effect may be related to the inhibition by propranolol of CoQ10-enzymes of the myocardium. Timolol showed negligible inhibition of the CoQ10-enzyme, NADH-oxidase. Metoprolol was less inhibitory than propranolol. Five alprenolols showed inhibition which approached that of propranolol. The 1-isomer of alprenolol showed weak inhibition of another CoQ10-enzyme, succinoxidase, but the other beta-blockers were essentially non-inhibitory to this enzyme. The drug of choice is timolol, based on negligible inhibition of these bioenergetic enzymes of the heart, which correlates with its pharmacologically low cardiac depressant effects.

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