Construction of an open-access database that integrates cross-reference information from the transcriptome and proteome of immune cells

Bioinformatics. 2007 Nov 1;23(21):2934-41. doi: 10.1093/bioinformatics/btm430. Epub 2007 Sep 24.


Motivation: Although a huge amount of mammalian genomic data does become publicly available, there are still hurdles for biologists to overcome before such data can be fully exploited. One of the challenges for gaining biological insight from genomic data has been the inability to cross-reference transcriptomic and proteomic data using a single informational platform. To address this, we constructed an open-access database that enabled us to cross-reference transcriptomic and proteomic data obtained from immune cells.

Results: The database, named RefDIC (Reference genomics Database of Immune Cells), currently contains: (i) quantitative mRNA profiles for human and mouse immune cells/tissues obtained using Affymetrix GeneChip technology; (ii) quantitative protein profiles for mouse immune cells obtained using two-dimensional gel electrophoresis (2-DE) followed by image analysis and mass spectrometry and (iii) various visualization tools to cross-reference the mRNA and protein profiles of immune cells. RefDIC is the first open-access database for immunogenomics and serves as an important information-sharing platform, enabling a focused genomic approach in immunology.

Availability: All raw data and information can be accessed from The microarray data is also available at under CIBEX accession no. CBX19, and under PRIDE accession numbers 2354-2378 and 2414.

MeSH terms

  • Animals
  • Database Management Systems*
  • Databases, Factual*
  • Humans
  • Information Storage and Retrieval / methods*
  • Internet*
  • Lymphocytes / immunology*
  • Proteome / immunology*
  • Systems Integration
  • Transcription Factors / immunology*


  • Proteome
  • Transcription Factors