Cutting and stitching: the cross-linking of peptidoglycan in the assembly of the bacterial cell wall

ACS Chem Biol. 2007 Sep 21;2(9):602-5. doi: 10.1021/cb700182u.

Abstract

The machinery responsible for bacterial cell wall synthesis has proven to be an invaluable antibiotic target. Nearly 80 years after the discovery of penicillin, some of the mysteries surrounding this process are finally being unraveled.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Bacteria / enzymology
  • Bacteria / metabolism
  • Bacterial Proteins / metabolism
  • Cell Wall / chemistry
  • Cell Wall / metabolism
  • Penicillin-Binding Proteins / chemistry
  • Penicillin-Binding Proteins / metabolism*
  • Penicillins / chemistry
  • Penicillins / metabolism*
  • Peptidoglycan / chemistry*
  • Peptidoglycan / metabolism*

Substances

  • Bacterial Proteins
  • Penicillin-Binding Proteins
  • Penicillins
  • Peptidoglycan