Neuronal regulation of alternative pre-mRNA splicing

Nat Rev Neurosci. 2007 Nov;8(11):819-31. doi: 10.1038/nrn2237.


Alternative pre-mRNA splicing has an important role in the control of neuronal gene expression. Many neuronal proteins are structurally diversified through the differential inclusion and exclusion of sequences in the final spliced mRNA. Here, we discuss common mechanisms of splicing regulation and provide examples of how alternative splicing has important roles in neuronal development and mature neuron function. Finally, we describe regulatory proteins that control the splicing of some neuronally expressed transcripts.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alternative Splicing / genetics*
  • Animals
  • Central Nervous System / embryology
  • Central Nervous System / physiology
  • Gene Expression
  • Gene Expression Regulation / physiology*
  • Humans
  • Neurons / physiology*
  • RNA Precursors / genetics*


  • RNA Precursors