Optic nerve dysfunction in a child following low-dose maternal warfarin exposure

Ophthalmic Genet. 2007 Sep;28(3):183-4. doi: 10.1080/13816810701537408.

Abstract

Because the embryopathy associated with maternal warfarin use seems dose-dependent, some physicians advocate low-dose warfarin for pregnant women requiring anticoagulation. The current case, however, highlights that optic nerve dysfunction (as well as other signs of warfarin embryopathy) can occur after low-dose maternal warfarin exposure.

Publication types

  • Case Reports

MeSH terms

  • Abnormalities, Drug-Induced
  • Anticoagulants / administration & dosage
  • Anticoagulants / adverse effects*
  • Anticoagulants / therapeutic use
  • Dose-Response Relationship, Drug
  • Face / abnormalities
  • Female
  • Humans
  • Infant
  • Nails, Malformed / chemically induced
  • Nails, Malformed / pathology
  • Optic Nerve Diseases / chemically induced*
  • Pregnancy
  • Pregnancy Complications, Cardiovascular / drug therapy
  • Pregnancy Trimester, First
  • Prenatal Exposure Delayed Effects*
  • Venous Thrombosis / drug therapy
  • Warfarin / administration & dosage
  • Warfarin / adverse effects*
  • Warfarin / therapeutic use

Substances

  • Anticoagulants
  • Warfarin