Trends in the exploration of therapeutic targets for the treatment of endocrine, metabolic and immune disorders

Endocr Metab Immune Disord Drug Targets. 2007 Sep;7(3):225-31. doi: 10.2174/187153007781662576.


A number of therapeutic targets have been explored for developing drugs in the treatment of endocrine, metabolic and immune disorders. Continuous efforts and increasing interest have been directed at the search of new targets. Data from the therapeutic target database at, shows that there are 26, 24, and 22 targets of marketed drugs for the treatment of these three classes of diseases, respectively. The number of targets of investigational agents has reached 98, 124, and 72, respectively. An analysis of these targets, particularly those of recently approved drugs and patented investigational agents, provides useful hint about the general trends of target exploration, with current focus on drug discovery and the difficulties encountered in developing drugs against these targets. Multiple profiles of these targets have been analyzed to probe the sequence, structural, physicochemical and systems-related features contributing to the successful exploration of a target against these diseases.

Publication types

  • Review

MeSH terms

  • Animals
  • Drug Approval
  • Endocrine System Diseases / drug therapy*
  • Humans
  • Immune System Diseases / drug therapy*
  • Metabolic Diseases / drug therapy*
  • Research
  • United States
  • United States Food and Drug Administration