Biological considerations on the use of zirconia for dental devices

Int J Immunopathol Pharmacol. 2007 Jan-Mar;20(1 Suppl 1):9-12. doi: 10.1177/039463200702001s03.


Zirconium oxide, known as zirconia, is a ceramic material with optimal esthetical and mechanical properties. Zirconia stabilized with yttrium oxide has the best properties for medical uses. A stress on ZrO2 surface creates a crystalline modification that opposes to propagation of cracks. Zirconia core for fixed partial dentures (FPD) on anterior and posterior teeth and on implants are now available. Clinical evaluations after 3 years report good percentage of success for zirconia fixed partial denture. Zirconia biocompatibility was studied in vivo and in vitro by orthopedic research; no adverse responses were reported on insertion of ZrO2 samples in bone or muscle. In vitro experimentation showed absence of mutation and a good viability of cells cultured on this material.

Publication types

  • Review

MeSH terms

  • Dental Implantation / instrumentation*
  • Denture, Partial, Fixed*
  • Humans
  • Zirconium / therapeutic use*


  • Zirconium
  • zirconium oxide