Capecitabine Induced Vasospastic Angina

Int J Cardiol. 2008 Oct 30;130(1):e34-6. doi: 10.1016/j.ijcard.2007.06.152. Epub 2007 Sep 25.

Abstract

Cardiotoxicity is a recognised side effect of intravenous 5-fluorouracils. In the two case reports described we demonstrate similar cardiotoxic side effects seen with the use of capecitabine. With the increasing use of oral adjuvant chemotherapeutic agents, capecitabine should be used with caution in those patients with existing coronary artery disease.

MeSH terms

  • Angina Pectoris / chemically induced*
  • Angina Pectoris / etiology
  • Antimetabolites, Antineoplastic / adverse effects*
  • Capecitabine
  • Coronary Vasospasm / chemically induced*
  • Coronary Vasospasm / complications
  • Deoxycytidine / adverse effects
  • Deoxycytidine / analogs & derivatives*
  • Fluorouracil / adverse effects
  • Fluorouracil / analogs & derivatives*
  • Humans

Substances

  • Antimetabolites, Antineoplastic
  • Deoxycytidine
  • Capecitabine
  • Fluorouracil