Recent findings from spatial cognition and cognitive neuroscience suggest that different types of mental representations could mediate the off-line retrieval of spatial relations from memory and the on-line guidance of motor actions in space. As a result, a number of models proposing multiple systems of spatial memory have been recently formulated. In the present article we review these models and we evaluate their postulates based on available experimental evidence. Furthermore, we discuss how a multiple-system model can apply to situations in which people reason about their immediate surroundings or non-immediate environments by incorporating a model of sensorimotor facilitation/interference. This model draws heavily on previous accounts of sensorimotor interference and takes into account findings from the stimulus-response compatibility literature.